Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 45, Pages 8163-8167Publisher
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v19.i45.8163
Keywords
Carcinogenesis; Colorectal cancer; Molecular pathology
Categories
Ask authors/readers for more resources
Colorectal carcinomas (CRCs) are frequently found in industrialized countries and lead to a high incidence of malignancy-related mortality. Defined by histomorphological features, CRCs and their pre-invasive lesions are quite heterogeneous. The underlying molecular mechanisms include genomic instability, genomic mutation of tumor suppressor genes or oncogenes, epigenetic changes, and the microRNA network. The molecular mechanisms are guided by repeated clonal selections. The genotype-to-phenotype relation is assumed to be the great challenge of cancer research and the development of effective targeted therapies. At present a strong genotype-to-phenotype relation is characterized only for a minority of CRCs. Consequently, the molecular characterization of CRCs is essential to interpret histological patterns and to identify prognostic groups as well as patients for targeted therapy. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available