Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 47, Pages 8861-8866Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i47.8861
Keywords
Hepatocellular carcinoma; Hepatitis B virus; Recurrence; Nucleotide analogues; Interferon
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Hepatocellular carcinoma (HCC) is the most common malignancy and the third leading cause of cancer death worldwide. Chronic infection with hepatitis B virus (HBV) and hepatitis C virus accounts for approximately 75%-80% of HCC cases worldwide. In particular, chronic HBV infection is a predominant risk factor for HCC in Asia and Africa. Hepatic resection and radiofrequency ablation are increasingly used for the curative treatment of HCC, and good local control can be achieved. However, the high rate of recurrence is a major obstacle to improving prognosis. A high viral load of HBV DNA is the most important correctable risk factor for recurrence. Furthermore, interferon and/or nucleotide analogues may decrease HBV DNA. Therefore, these drugs may decrease recurrence. In this article, treatment strategies for HBV-related HCC are described in order to reduce recurrence and improve survival. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
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