Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 15, Pages 2307-2312Publisher
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v19.i15.2307
Keywords
Barrett's esophagus; Interleukin 6; Bile acids; Inflammation; Apoptosis
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Funding
- National Cancer Institute [p50 CA95060]
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Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus arising as a consequence of chronic gastroesophageal reflux disease. Multiple studies show that BE is associated with increased risk of esophageal adenocarcinoma (EAC). Epidemiological studies and animal models demonstrate that chronic inflammation triggered by repeated exposure to refluxate predisposes to the development of BE and EAC. The chronic inflammation is associated with cytokine alterations. Interleukin 6 (IL-6) is a cytokine that stimulates cell proliferation and apoptosis resistance is frequently increased in different cancers. Importantly, IL-6 and transcriptional factor signal transducer and activator of transcription 3 (STAT3) that is activated by IL-6 are also increased in BE and EAC. This review critically appraises the role of IL-6/STAT3 pathway in progression of BE to EAC from the published evidence currently available. (C) 2013 Baishideng. All rights reserved.
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