Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 43, Pages 7544-7551Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i43.7544
Keywords
Optical biopsy; Confocal endomicroscopy; Endocytoscopy; Dysplasia; Mucosal inflammation; Disease relapse; Mucosal healing; Barrier function
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Funding
- Canadian Institute of Health Research
- Canadian Association of Gastroenterology
- Crohn's and Colitis Foundation of Canada
- Stockholm County Council
- Karolinska Institute
- American Society for Gastrointestinal Endoscopy Cook Medical Don Wilson Award
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In this review, we will discuss the use of two optical biopsy modalities in inflammatory bowel disease (IBD). The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy. We will describe the technical performance of the procedure, discuss the clinical indications for optical biopsy in IBD, and highlight active research areas with respect to the pathogenesis of IBD. Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation, dysplasia detection and evaluation of cell shedding for disease relapse. Research application in the area of barrier dysfunction will also be discussed. (C) 2013 Baishideng Publishing Group co., Limited. All rights reserved.
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