Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 18, Issue 39, Pages 5495-5503Publisher
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v18.i39.5495
Keywords
Zollinger-Ellison syndrome; Gastrinoma; Hypergastrinemia; Secretin test; Serum gastrin; Gastrin; Neuroendocrine tumor
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In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management. (C) 2012 Baishideng. All rights reserved.
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