Prevalence of functional dyspepsia and its subgroups in patients with eating disorders

AIM: To study the prevalence of functional dyspepsia (FD) (Rome M criteria) across eating disorders (ED), obese patients, constitutional thinner and healthy volunteers. METHODS: Twenty patients affected by anorexia nervosa, 6 affected by bulimia nervosa, 10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders, 4th edition, nine constitutional thinner subjects and, thirty-two obese patients were recruited from an outpatients clinic devoted to eating behavior disorders. Twenty-two healthy volunteers matched for age and gender were enrolled as healthy controls. All participants underwent a careful clinical examination. Demographic and anthropometric characteristics were obtained from a structured questionnaires. The presence of FD and, its subgroups, epigastric pain syndrome and postprandial distress syndrome (PDS) were diagnosed according to Rome III criteria. The intensity-frequency score of broader dyspeptic symptoms such as early satiety, epigastric fullness, epigastric pain, epigastric burning, epigastric pressure, belching, nausea and vomiting were studied by a standardized questionnaire (0-6). Analysis of variance and post-hoc Sheffe tests were used for comparisons. RESULTS: 90% of patients affected by anorexia nervosa, 83.3% of patients affected by bulimia nervosa, 90% of patients affected by ED not otherwise specified, 55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria (chi(2), P < 0.001). Only one bulimic patient met the epigastric pain syndrome diagnosis. Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa, bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group (4.15 +/- 2.08 vs 1.44 +/- 2.35, P = 0.003; 5.00 +/- 2.45 vs 1.44 +/- 2.35, P = 0.003; 4.10 +/- 2.23 vs 1.44 +/- 2.35, P = 0.002, respectively), the obese group (4.15 2.08 vs 0.00 +/- 0.00, P < 0.001; 5.00 +/- 2.45 vs 0.00 +/- 0.00, P < 0.001; 4.10 +/- 2.23 vs 0.00 +/- 0.00, P < 0.001, respectively) and healthy volunteers (4.15 +/- 2.08 vs 0.36 +/- 0.79, P < 0.001; 5.00 +/- 2.45 vs 0.36 +/- 0.79, P < 0.001; 4.10 +/- 2.23 vs 0.36 +/- 0.79, P < 0.001, respectively). Early satiety intensity-frequency score was prominent in anorectic patients compared to bulimic patients (3.85 2.23 vs 1.17 +/- 1.83, P = 0.015), obese patients (3.85 2.23 vs 0.00 +/- 0.00, P < 0.001) and healthy volunteers (3.85 +/- 2.23 vs 0.05 +/- 0.21, P < 0.001). Nausea and epigastric pressure were increased in bulimic and ED not otherwise specified patients. Specifically, nausea intensity-frequencyscore was significantly higher in bulimia nervosa and ED not otherwise specified patients compared to anorectic patients (3.17 +/- 2.56 vs 0.89 +/- 1.66, P = 0.04; 2.70 +/- 2.91 vs 0.89 +/- 1.66, P = 0.05, respectively), constitutional thinner subjects (3.17 +/- 2.56 vs 0.00 +/- 0.00, P = 0.004; 2.70 +/- 2.91 vs 0.00 +/- 0.00, P = 0.005, respectively), obese patients (3.17 +/- 2.56 vs 0.00 +/- 0.00, P < 0.001; 3.17 +/- 2.56 vs 0.00 +/- 0.00, P < 0.001 respectively) and, healthy volunteers (3.17 +/- 2.56 vs 0.17 +/- 0.71, P = 0.002; 3.17 +/- 2.56 vs 0.17 +/- 0.71, P = 0.001, respectively). Epigastric pressure intensityfrequency score was significantly higher in bulimic and ED not otherwise specified patients compared to constitutional thin subjects (4.67 +/- 2.42 vs 1.22 +/- 1.72, P = 0.03; 4.20 +/- 2.21 vs 1.22 +/- 1.72, P = 0.03, respectively), obese patients (4.67 +/- 2.42 vs 0.75 +/- 1.32, P = 0.001; 4.20 +/- 2.21 vs 0.75 +/- 1.32, P < 0.001, respectively) and, healthy volunteers (4.67 2.42 vs 0.67 +/- 1.46, P = 0.001; 4.20 +/- 2.21 vs 0.67 +/- 1.46, P = 0.001, respectively). Vomiting was referred in 100% of bulimia nervosa patients, in 20% of ED not otherwise specified patients, in 15% of anorexia nervosa patients, in 22% of constitutional thinner subjects, and, in 5.6% healthy volunteers (chi(2), P < 0.001). CONCLUSION: PDS is common in eating disorders. Is it mandatory in outpatient gastroenterological clinics to investigate eating disorders in patients with PDS? (C) 2012 Baishideng. All rights reserved.