Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 18, Issue 43, Pages 6189-6196Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v18.i43.6189
Keywords
miRNAs; Cholangiopathies; Cholangiocarcinoma; Polycystic liver diseases; Primary biliary cirrhosis
Categories
Funding
- Spanish Carlos III Institute
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Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expression, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted. (C) 2012 Baishideng. All rights reserved.
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