Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 11, Pages 1366-1376Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i11.1366
Keywords
Cytochrome P450 2E1; S-adenosyl-L-methionine; Ethanol; Toxic hepatitis; Oxidative stress
Categories
Funding
- NIH/NIAAA [AA017425, AA018790]
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S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection. (C) 2010 Baishideng. All rights reserved.
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