Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 40, Pages 5118-5121Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i40.5118
Keywords
Helicobacter pylori; Antibiotic resistance; Agar dilution; Metronidazole; Clarithromycin; Levofloxacin; Tetracycline; Amoxicillin; Furazolidone
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Funding
- National Natural Science Foundation of China [30770112]
- Shanghai Leading Academic Discipline Project [Y0205]
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AIM: To investigate the resistance of Helicobacter pylori (H. pylon) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases. (C) 2010 Baishideng. All rights reserved.
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