Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 12, Pages 1482-1486Publisher
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v16.i12.1482
Keywords
Recql5; Apc; Tumor suppressor; Genome instability; Colon cancer; Apc(min/+) mice
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Funding
- US National Institutes of Health [RO1 CA88939, P20 CA 103736]
- Searle Scholar Program [01-E-109]
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AIM: To investigate whether Recql5, a DNA helicase that plays an important role in the maintenance of genome integrity, is a tumor suppressor in the gastrointestinal tract in mice. METHODS: We generated cohorts of both Recql5-proficient and Recql5-deficient Apc(min/+) mice and compared the tumor susceptibility in their gastrointestinal tracts. RESULTS: Recql5 deficiency in Apc(min/+) mice resulted in a significant increase in the tumor incidence in both the colon (P = 0.0162) and the small intestine (P < 0.01). These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice. Importantly, since mouse Recql5 and human RECQL5 are highly conserved, these findings also suggest that RECQL5 may be a tumor suppressor for human colon cancer. CONCLUSION: Recql5 has a tumor suppression role in the mouse gastrointestinal tract. (C) 2010 Baishideng. All rights reserved.
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