Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 29, Pages 3697-3703Publisher
W J G PRESS
DOI: 10.3748/wjg.v16.i29.3697
Keywords
Early onset colorectal cancer; Microsatellite instability; Lynch syndrome; Microsatellite stable colorectal cancer
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Funding
- The Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo [FIS01-04, PO47-04]
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AIM: To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI). METHODS: Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies. RESULTS: Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E, which could be a marker of poor prognosis. beta-catenin expression was normal in a high percentage of tumors. CONCLUSION: Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor. (C) 2010 Baishideng. All rights reserved.
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