Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 24, Pages 2980-2986Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.2980
Keywords
Stress; Chronic viral hepatitis; Cirrhosis; Carcinoma; Hepatocellular; Liver pathology
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Psychosocial stress is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflammatory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. (c) 2009 The WJG Press and Baishideng. All rights reserved.
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