Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 48, Pages 6023-6027Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.6023
Keywords
Genetics; Liver fibrosis; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Single nucleotide polymorphisms
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Funding
- NCI NIH HHS [R33 CA094304] Funding Source: Medline
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The spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis through steatohepatitis to advanced fibrosis and cirrhosis. Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear, recent research has identified genetic factors as a possible basis for this variation in disease presentation. Most of the studies have been focused on finding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis. Although there are many limitations regarding the study design and interpretation of published data, further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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