Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 17, Pages 2049-2066Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.2049
Keywords
Cholestasis; Pregnancy; Pruritus; Bile acid
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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICR (C) 2009 The WJG Press and Baishideng. All rights reserved.
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