Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 35, Pages 4464-4466Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.4464
Keywords
Sorafenib; Tumor lysis syndrome; Hepatocellular carcinoma; Hemodialysis; Hyperkalemia
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A 55-year-old male patient with hepatitis B-related liver cirrhosis was found to have advanced hepatocellular carcinoma. His AFP was initially 9828 mu g/L and rapidly dropped to 5597 mu g/L in ten days after oral sorafenib treatment. However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment. Tumor lysis syndrome was suspected and intensive hemodialysis was performed. Despite intensive hemodialysis and other supportive therapy, he developed multiple organ failure (liver, renal, and respiratory failure) and metabolic acidosis. The patient expired 13 d after admission. (C) 2009 The WIG Press and Baishideng. All rights reserved
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