Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 22, Pages 2800-2804Publisher
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.15.2800
Keywords
Semaphorin 5A; Plexin B3; Gastric carcinoma; Invasion; Metastasis
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AIM: To investigate the protein and mRNA expression of semaphorin 5A and its receptor plexin 133 in gastric carcinoma and explore its role in the invasion and metastasis of gastric carcinoma. METHODS: Expression of semaphorin 5A and its receptor plexin B3 in 48 samples of primary gastric carcinoma, its corresponding non-neoplastic mucosa, and matched regional lymph node metastasis was assayed by reverse transcription-polymerase chain reaction (RT-PCR), real-time RT-PCR and Western blotting. RESULTS: The protein and mRNA expression of semaphorin 5A and its receptor plexin B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma and lymph node metastasis (P < 0.05). Moreover, the expression of semaphorin 5A was closely correlated with that of plexin B3. CONCLUSION: Semaphorin 5A and its receptor plexin B3 play an important role in the invasion and metastasis of gastric carcinoma. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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