Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 46, Pages 5799-5804Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.5799
Keywords
Electrophysiology; Interstitial cells of Cajal; TRPM cation channels; Transient receptor potential melastatin-type 7 protein; Human; Gastrointestinal tract
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AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract. METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs). RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La3+, TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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