Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 24, Pages 3781-3791Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.3781
Keywords
primary sclerosing cholangitis; autoantibodies; autoimmunity; antibodies against cytoplasmic constituents of neutrophil; tropomyosin
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The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients, but the specificity of these antibodies is generally low, and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecific dysregulation of the immune system, but the literature in PSC points to the possible presence of specific antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC, with a particular emphasis on the prevalence, clinical relevance and possible pathogenetic importance of each individual marker. (C) 2008 The WJG Press. All rights reserved.
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