Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 1, Pages 22-28Publisher
W J G PRESS
DOI: 10.3748/wjg.14.22
Keywords
non-alcoholic fatty liver disease; peroxisome proliferators-activated receptors; insulin resiatance; metabolic syndrome; pharmacologic ligands
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Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. The aim of this review is to describe the data linking PPAR alpha and PPAR gamma to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH.
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