Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 40, Pages 6115-6121Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.6115
Keywords
Inflammatory bowel diseases; WNK; NKCC1; Barrier function; Ste20-related proline/alaninerich kinase
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Recently, inflammatory bowel disease (IBD) has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function. SPAK is known to interact with inflammation-related kinases (such as p38, INK, NKCC1, PKC theta, WNK and MLCK), and with transcription factor AP-1, resulting in diverse biological phenomena, including cell differentiation, cell transformation and proliferation, cytoskeleton rearrangement, and regulation of chloride transport. This review examines the involvement of Ste20-like kinases and downstream mitogen-activated protein kinases (MAPKs) pathways in the pathogenesis and control of intestinal inflammation. The primary focus will be on the molecular features of intestinal inflammation, with an emphasis on the interaction between SPAK and other molecules, and the effect of these interactions on homeostatic maintenance, cell volume regulation and increased cell permeability in intestinal inflammation. (C) 2008 The WJG Press. All rights reserved.
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