Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 12, Issue 7, Pages 528-538Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/15622975.2011.559270
Keywords
Sexual dysfunction; 5-HTTLPR; selective serotonin uptake inhibitors; escitalopram; nortriptyline
Categories
Funding
- European Commission [LSHB-CT-2003-503428]
- GlaxoSmithKline
- Medical Research Council (UK)
- Biomedical Research Centre for Mental Health at the South London
- Maudsley NHS Foundation Trust
- Institute of Psychiatry, King's College London (National Institute for Health Research, Department of Health, UK)
- German Research Foundation [GRK 793]
- Lundbeck
- Bristol-Myers Squibb
- Medical Research Council [G9817803B] Funding Source: researchfish
Ask authors/readers for more resources
Objectives. Sexual dysfunction (SD) is a frequently reported side-effect of antidepressant treatment, particularly of selective serotonin reuptake inhibitors (SSRIs). In the multicentre clinical and pharmacogenetic GENDEP study (Genome-based Therapeutic Drugs for Depression), the effect of the serotonin transporter gene promoter polymorphism 5-HTTLPR on sexual function was investigated during treatment with escitalopram (SSRI) and nortriptyline (tricyclic antidepressant). Methods. A total of 494 subjects with an episode of DSM-IV major depression were randomly assigned to treatment with escitalopram or nortriptyline. Over 12 weeks, depressive symptoms and SD were measured weekly with the Montgomery-Asberg Depression Rating Scale, the Antidepressant Side-Effect Checklist, the UKU Side Effect Rating Scale, and the Sexual Functioning Questionnaire. Results. The incidence of reported SD after 12 weeks of treatment was relatively low, and did not differ significantly between antidepressants (14.9% escitalopram, 19.7% nortriptyline). There was no significant interaction between the 5-HTTLPR and antidepressant on SD. Improvement in depressive symptoms and younger age were both associated with lower SD. The effect of age on SD may have been moderated by the 5-HTTLPR. Conclusions. In GENDEP, rates of reported SD during treatment were lower than those described in previous reports. There was no apparent effect of the 5-HTTLPR on the observed decline in SD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available