Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 12, Issue 1, Pages 33-41Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/15622975.2010.518628
Keywords
Suicide; aggression; HTR2A; 5HTTLPR; MAOA; polymorphism
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Funding
- Sacta-Rashi Foundation
- Harrison Foundation
- Ministry of Health
- National Institute for Psychobiology in Israel [99/9b]
- Judie and Marshall Polk Research Fund for Children at Risk
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Objectives. Suicidal behaviour runs in families. This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents. Methods. Four groups of adolescents were included: Suicidal (N = 35) and non-suicidal (N = 30) psychiatric inpatients, suicide attempters admitted to three psychiatric emergency rooms (N = 51) and a community-based control group (N = 95). All were genotyped and underwent psychological assessment for relevant endophenotypes and plasma serotonin content (p5HT) was measured. Results. Homozygosity for the T allele of the HTR2A 102T/C polymorphism was associated with lower impulsivity (P = 0.03) and aggression (P = 0.01) compared to TC carriers. Low activity MAOA genotypes were associated with suicidality (P = 0.04). No association was found between p5HT level and the examined polymorphisms. Conclusions. Our findings are in line with the associations described in adult suicidal population. Further studies are needed to evaluate the gene x environmental interactions in larger samples in an attempt to clarify the possible role of genetic factors in pediatric suicidal and impulsive-aggressive behaviour.
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