Journal
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
Volume 4, Issue 6, Pages 605-619Publisher
WILEY-BLACKWELL
DOI: 10.1002/wnan.1186
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Funding
- Vanderbilt Institute of Nanoscale Science and Engineering (VINSE)
- US National Institute of Health [EB003728, GM72048, MH07802, MH094527]
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The ability to efficiently visualize protein targets in cells is a fundamental goal in biological research. Recently, quantum dots (QDots) have emerged as a powerful class of fluorescent probes for labeling membrane proteins in living cells because of breakthrough advances in QDot surface chemistry and biofunctionalization strategies. This review discusses the increasing use of QDots for fluorescence imaging of neuronal receptors and transporters. The readers are briefly introduced to QDot structure, photophysical properties, and common synthetic routes toward the generation of water-soluble QDots. The following section highlights several reports of QDot application that seek to unravel molecular aspects of neuronal receptor and transporter regulation and trafficking. This article is closed with a prospectus of the future of derivatized QDots in neurobiological and pharmacological research. WIREs Nanomed Nanobiotechnol 2012, 4:605619. doi: 10.1002/wnan.1186 For further resources related to this article, please visit the WIREs website.
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