Journal
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
Volume 3, Issue 1, Pages 79-85Publisher
WILEY
DOI: 10.1002/wnan.112
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Funding
- National Institutes of Health [1R01ES014774, R01-EB006201]
- US Army Medical Research and Material Command [W81XWH-09-1-0064]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006201] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES014774] Funding Source: NIH RePORTER
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This article is a review on the design, fabrication, and applications of fiberoptic nanosensors for in vivo monitoring of individual living cells. The nanosensors were fabricated with tapered optical fibers with distal ends having nanometer-sized diameters. Bioreceptors, such as antibody, peptides, and nucleic acids, are immobilized on the fiber tips and designed to be selective to target analyte molecules of interest. A laser beam is transmitted into the fiber, producing an evanescent field at the tip of the nanofiber that is used to excite target molecules bound to the bioreceptor molecules. The fluorescence originated from the analyte molecules is detected by a photo-detection system. The advantages and limitations of nanosensors in providing minimally invasive tools to probe subcellular compartments inside individual living cells for health effect studies and medical applications are discussed in detail. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2011 3 79-85 DOI: 10.1002/wnan.112
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