Journal
HAEMATOLOGICA
Volume 100, Issue 11, Pages 1376-1387Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2014.113852
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Funding
- LOEWE Center for Cell and Gene Therapy Frankfurt (CGT)
- Georg-Speyer-Haus
- German Federal Ministry of Health (BMG)
- Ministry of Higher Education, Research and the Arts of the State of Hessen (HMWK)
- HMWK [III L 4-518/17.004]
- [U54 CA163191]
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Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging tools. Less well understood, but of growing interest, is the interaction between cells in the bone marrow during the initiation, maintenance and treatment of hematologic neoplasms. This review summarizes the emerging concepts of the normal and leukemic hematopoietic bone marrow niche. Furthermore, it reviews current models of how the microenvironment of the bone marrow may contribute to or be modified by leukemogenesis. Finally, it provides the rationale for a two-pronged approach, directly targeting cancer cells themselves while also targeting the bone microenvironment to make it inhospitable to malignant cells and, ultimately, eradicating cancer stem-like cells.
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