Journal
FRONTIERS IN MICROBIOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2015.01036
Keywords
Pseudomonas aeruginosa; next-generation sequencing; bacterial genome; phylogeny; database; cystic fibrosis; antibiotic resistance; clinical microbiology
Categories
Funding
- Cystic Fibrosis Canada postdoctoral fellowship
- Cystic Fibrosis Canada
- CIHR-UK team grant
- UK Cystic Fibrosis Trust
- Fight for Sight
- NIH [P30 DK089507]
- Queensland Health Fellowship
- NHMRC [455919]
- TPCH Foundation
- ERS-EU RESPIRE2 Marie Sklodowska-Curie Postdoctoral Research Fellowship-MC RESPIRE2 [4571-2013]
- Cure Kids, Cystic Fibrosis New Zealand
- New Zealand Lotteries Board (Health)
- Cisco Systems Canada, Inc.
- Canadian Institutes of Health Research (CIHR) [MOP-142466]
- Natural Sciences and Engineering Research Council (NSERC)
- Canada Research Chair
- CIHR Doctoral research award
- Cystic Fibrosis Foundation Therapeutics
- Genome Canada
- Biotechnology and Biological Sciences Research Council [BB/K019600/1] Funding Source: researchfish
- Medical Research Council [MR/M501621/1] Funding Source: researchfish
- Villum Fonden [00007262] Funding Source: researchfish
- BBSRC [BB/K019600/1] Funding Source: UKRI
Ask authors/readers for more resources
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aerugihosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care.
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