Journal
VISION RESEARCH
Volume 50, Issue 23, Pages 2322-2333Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2010.03.021
Keywords
Gene expression; Myopia; Eye growth; Models; Microarrays; Profiling
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Funding
- NIH [R21-EY015760, R01-EY018838, R01-EY013862]
- Paul and Evanina Bell Mackall Foundation Trust
- Research to Prevent Blindness
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To understand the complex regulatory pathways that underlie the development of refractive errors, expression profiling has evaluated gene expression in ocular tissues of well-characterized experimental models that alter postnatal eye growth and induce refractive errors. Derived from a variety of platforms (e.g. differential display, spotted microarrays or Affymetrix GeneChips), gene expression patterns are now being identified in species that include chicken, mouse and primate. Reconciling available results is hindered by varied experimental designs and analytical/statistical features. Continued application of these methods offers promise to provide the much-needed mechanistic framework to develop therapies to normalize refractive development in children. (C) 2010 Elsevier Ltd. All rights reserved.
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