4.3 Article

Modulation of horizontal cell function by dopaminergic ligands in mammalian retina

Journal

VISION RESEARCH
Volume 48, Issue 12, Pages 1383-1390

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2008.03.004

Keywords

rabbit; intracellular recording; flicker responses; dopamine

Funding

  1. Intramural NIH HHS [Z01 NS002631-25] Funding Source: Medline

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Light responses of rabbit horizontal cell somata (HC) to flickering light stimuli recorded with sharp electrodes consist of a distinctive flicker component superimposed on a sustained hyperpolarisation. Activation of dopamine D1/D5 receptors depolarises HC dark membrane potential and suppresses the flicker component of responses to photopic stimuli without affecting the sustained hyperpolarising response component. Waveforms of responses to scotopic stimuli are preserved. Similar response modulation was observed in depolarising cells of the inner retina, suggesting that activation of D1/D5 receptors of HC causes modification of cone signal transmission to higher order neurons. The impact of dopamine D1/D5 receptor activation on the function of HC in the light stimulated retina is discussed. (C) 2008 Elsevier Ltd. All rights reserved.

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