Journal
VISION RESEARCH
Volume 48, Issue 2, Pages 223-234Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2007.11.002
Keywords
Muller glia; regeneration; photoreceptor degeneration; N-methyl-N-nitrosourea
Categories
Funding
- PHS HHS [EYF101011] Funding Source: Medline
Ask authors/readers for more resources
To determine whether photoreceptor degeneration can stimulate Muller glia to transdifferentiate into neurons in adult mammalian retina, N-methyl-N-nitrosourea (MNU) was injected to induce complete loss of photoreceptors. Following MNU administration, Muller glia underwent reactive gliosis characterized by up-regulation of glial fibrillar acidic protein and nestin, and initiated proliferation through the cyclin D1 and D3 related pathways. Some Muller glia-derived cells were induced to express rhodopsin exclusively. These rh odopsin-positive cells exhibited synaptophysin around them, suggesting possible formation of synapses. After transplanted in to damaged retina, Muller glia migrated, grafted in host retina and produced rhodopsin. These results suggest that degeneration may promote preferential differentiation of Muller glia to photoreceptors and provide a potential therapeutic strategy for retinal degenerative diseases. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available