Journal
VIRUS RESEARCH
Volume 188, Issue -, Pages 32-37Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2014.03.016
Keywords
Herpes simplex virus type 1 (HSV-1); Calcium signal; Nuclear transport; Slingshot 1; Calpain-1
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Funding
- Twelfth Five-Year National Science and Technology Support Program [2012BAI29B06]
- National Natural Science Foundation of China [81274170]
- Foundation for High-level Talents in Higher Education of Guangdong, China [79]
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Herpes simplex virus type 1 (HSV-1) can establish its latency in neurons and is associated with virus-induced pathological neurodegeneration in the nervous system. Here we show that viral penetration-induced calcium release facilitated HSV-1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics. More detailed studies revealed that phospholipase C gamma 1, and the inositol 1,4,5-trisphosphate receptor isoform 1 were required for SSH activation. Besides, calpain-1, a calcium-dependent cysteine protease, was involved in viral intracellular migration. These results may lead to new targets for antiviral therapy. (C) 2014 Elsevier B.V. All rights reserved.
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