Journal
VIRUS RESEARCH
Volume 194, Issue -, Pages 191-199Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2014.09.009
Keywords
CoV; SARS-CoV; 2 ' O-Methyl-transferase; 2 ' O-MTase; NSP16; MDA5
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Funding
- National Institute Of Allergy & Infectious Diseases of the NIH [HHSN272200800060C, U19A1100625, U19A1109761, F32A1102561]
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The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) Coy, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of NSP16, a 2'O-methyl-transferase (2'O-MTase), in CoV infection and the host immune response. The review highlights conserved motifs, required interaction partners, as well as the attenuation of NSP16 mutants, and restoration of these mutants in specific immune knockouts. Importantly, the work also identifies a number of approaches to exploit this understanding for therapeutic treatment and the data clearly illustrate the importance of NSP16 2'O-MTase activity for Coy infection and pathogenesis. (C) 2014 Published by Elsevier B.V.
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