Journal
VIRUS RESEARCH
Volume 178, Issue 1, Pages 15-20Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2013.07.017
Keywords
Avian H5N1 influenza A virus; Airborne transmission; Mammalian model
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Ministry of Health, Labour and Welfare, Japan
- ERATO (Japan Science and Technology Agency)
- European Union
- National Institute of Allergy and Infectious Diseases Public Health Service research grants
- [HHSN266200700010C]
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Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness. (C) 2013 Elsevier B.V. All rights reserved.
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