Journal
VIRUS RESEARCH
Volume 164, Issue 1-2, Pages 10-19Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2011.10.007
Keywords
Porcine circovirus type 2 (PCV2); Clinical signs; Pathology; Diagnosis
Categories
Funding
- European Union [513928]
- Ministerio de Educacion y Ciencia of Spain [GEN2003-20658-C05-02]
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Clinical signs and pathological features are still the corner-stones to suspect and diagnose overt disease associated with PCV2 infection. The clinico-pathological scope of this viral infection has been expanded over time. From the initial description of postweaning multisystemic wasting syndrome, some enteric, respiratory and reproductive disorders have been subsequently linked with PCV2. Porcine dermatitis and nephropathy syndrome, an immunocomplex disease, has also been associated with infection by this virus. All together, these conditions have been grouped under the name of porcine circovirus diseases (PCVD) or porcine circovirus associated diseases (PCVAD). The precise mechanisms by which a PCV2 infected pig develops a PCV2 subclinical infection or a clinical PCVD/PCVAD are still to be fully elucidated, but inferences based upon clinical, gross and histologic findings from field cases of disease have been useful to suggest the pathogenesis of this viral infection. The objective of the present review is to update the current knowledge on the clinical and pathological scope of PCV2 infections, as well as on their diagnosis. Moreover, a proposal on a unified PCVD/PCVAD terminology and clearly defined diagnostic criteria for these conditions are also given. (C) 2011 Elsevier B.V. All rights reserved.
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