Journal
VIRUS RESEARCH
Volume 157, Issue 1, Pages 82-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2011.02.010
Keywords
HIV-1; vpr; SRp55; Splicing
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Funding
- Swedish International Development Cooperation Agency
- Swedish Research Council
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We have previously shown that SRp55 inhibits splicing from HIV-1 exon 3, thereby generating partially spliced mRNAs encoding HIV-1 vpr. Here we show that SRp55 also inhibits splicing from HIV-1 exon 5 to generate HIV-1 vpu/env mRNA, albeit with lower efficiency. We also show that inhibition of HIV-1 splicing by SRp55 causes the appearance of partially spliced vpu, env and vpr mRNAs in the cytoplasm. SRp55 could also induce production of extracellular p24gag from a rev-defective HIV-1 provirus. These results indicate that SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. (C) 2011 Elsevier B.V. All rights reserved.
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