Journal
VIRUS RESEARCH
Volume 151, Issue 2, Pages 205-212Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2010.05.008
Keywords
Hantavirus; Protein interaction; Zinc finger
Categories
Funding
- Academy of Finland
- Sigrid Juselius Foundation, Finland
- Graduate School on Biotechnology and Molecular Biology
- Helsinki Biomedicum Graduate School
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Hantaviral N and Gn proteins were shown to interact, thus providing the long-awaited evidence for one of the crucial steps in the virus replication at which RNPs are directed to the site of the virus assembly. Using pull-down assay and point mutagenesis it was demonstrated that intact, properly folded zinc fingers in the Gn protein cytoplasmic tail as well as the middle domain of the N protein (that includes aa residues 80-248) are essential for the interaction. (C) 2010 Elsevier B.V. All rights reserved.
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