Journal
VIRUS RESEARCH
Volume 139, Issue 2, Pages 166-171Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2008.06.004
Keywords
Hepatitis C virus (HCV); Internal ribosome entry site (IRES); NMR spectroscopy; RNA structure
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Funding
- MRC [MC_U105170649] Funding Source: UKRI
- Medical Research Council [MC_U105170649] Funding Source: researchfish
- Medical Research Council [MC_U105170649] Funding Source: Medline
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The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, 1 discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical, protein-based eukaryotic initiation factors. (c) 2008 Elsevier B.V. All rights reserved.
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