Journal
VIRUS RESEARCH
Volume 131, Issue 2, Pages 213-223Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2007.09.011
Keywords
cytomegalovirus; IL-10; vIL-10
Categories
Funding
- NCRR NIH HHS [P20 RR020145, FRA-RR-03-014, P20 RR020145-037510] Funding Source: Medline
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Two products of human cytomegalovirus (HCMV) UL111a gene have been previously identified to resemble human IL-10 (hIL-10). These viral IL-10s (vIL-10s) are able to induce signal transduction events and biological activities in a variety of cells. In this study, five novel vIL-10 transcripts were identified from HCMV AD169 infected MRC-5 cells. Some vIL-10 isoforms were post-translationally glycosylated, depending on the existence of a predicted N-linked glycosylation site. Similar to hIL-10, four of the vIL-10 isoforms apparently formed putative dimers. Among the different vIL-10 isoforms, vIL-10A significantly induced the phosphorylation of transcription factor STAT3 in THP-1 cells. All identified vIL-10 isoforms were able to form complexes with hIL-10, and enhanced hfL-10-induced STAT3 phosphorylation in different degrees. Identification of diverse forms of vIL- 10 suggests that HCMV has developed a sophisticated mechanism to interfere with hIL-10 signaling pathway. (C) 2007 Elsevier B.V. All rights reserved.
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