Journal
VIRUS GENES
Volume 42, Issue 1, Pages 46-54Publisher
SPRINGER
DOI: 10.1007/s11262-010-0545-9
Keywords
RSV; G glycoprotein; Influenza; Cellular immunity; Vaccines
Categories
Funding
- Linda and Timothy O'Neill Institute at Georgetown University [AI-054952]
- Thrasher Research Fund
- Fogarty International Center at Vanderbilt [R24 TW007988]
- CONICET, Argentina
Ask authors/readers for more resources
The cytotoxic T-lymphocyte (CTL) response plays an important role in the control of respiratory syncytial virus (RSV) replication and the establishment of a Th1-CD4+ T cell response against the virus. Despite lacking Major Histocompatibility Complex I (MHC I)-restricted epitopes, the attachment G glycoprotein of RSV enhances CTL activity toward other RSV antigens, and this effect depends on its conserved central region. Here, we report that RSV-G can also improve CTL activity toward antigens from unrelated pathogens such as influenza, and that a mutant form of RSV-G lacking four conserved cysteine residues at positions 173, 176, 182, and 186 fails to enhance CTL responses. Our results indicate that these conserved residues are essential for the wide-spectrum pro-CTL activity displayed by the protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available