Journal
VIROLOGY JOURNAL
Volume 11, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12985-014-0205-0
Keywords
Virus; Vaccine; Biofarming; Plant-made antigen; Monoclonal antibody; HIV; HBV; HCV; HPV; Influenza; Bluetongue; Rabies; Ebola; ZMapp
Categories
Funding
- National Research Foundation
- Department of Science and Technology
- Poliomyelitis Research Foundation
- Medical Research Council
- University of Cape Town Research Committee in South Africa
- PlaProVa project of the EU FP7 initiative
- Era Biotech
- Medicago Inc.
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Plant-made or biofarmed viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.
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