Journal
VIROLOGY JOURNAL
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1743-422X-10-1
Keywords
Herpesviridae; Glycoprotein L; GL; UL130; Chemokines; HCMV; HSV2; EBV
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Funding
- Polish National Centre for Research and Development (NCBiR) INNOTECH Programme [IN1/159417]
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Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.
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