Journal
VIROLOGY JOURNAL
Volume 9, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1743-422X-9-301
Keywords
Chikungunya virus; Inactivated vaccine; Iodonapthyl azide
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Funding
- JSTO CBD/DTRA [4.10019_07_US_B]
- USAMRIID [G174QH]
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Background: Chikungunya virus (CHIKV) is an arthropod borne alphavirus of the family Togaviridae. CHIKV is a reemerging virus for which there is no safe prophylactic vaccine. A live attenuated strain of CHIKV, CHIK181/25, was previously demonstrated to be highly immunogenic in humans, however, it showed residual virulence causing transient arthralgia. Findings: In this study, we demonstrate the complete inactivation of CHIKV181/25 by 1,5 iodonapthyl azide (INA). No cytopathic effect and virus replication was observed in cells infected with the INA-inactivated CHIKV. However, a reduction in the INA-inactivated CHIK virus-antibody binding capacity was observed by western blot analysis. Conclusion: INA completely inactivated CHIKV and can further be explored for developing an inactivated-CHIKV vaccine.
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