Journal
VIROLOGY JOURNAL
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1743-422X-7-3
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Funding
- American Foundation of AIDS Research (amfAR) [106658-36-RFNT]
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HIV-1 particle assembly mediated by viral Gag protein occurs predominantly at plasma membrane. While colocalization of HIV-1 envelope with lipid rich microenvironment have been shown in T cells, the significance of viral proteins modulating envelope association in such microdomains in plasma membrane enriched in glycosylphosphatidylinositol-anchored proteins in primary CD4(+) T cells that are natural targets of HIV-1 is poorly understood. Here we show that in primary CD4(+) T cells that are natural targets of HIV-1 in vivo, Gag modulates HIV-1 envelope association with GM1 ganglioside and CD59 rich cellular compartments as well as with detergent resistant membranes. Our data strengthen evidence that Gag-Env interaction is important in envelope association with lipid rafts containing GPI-anchored proteins for efficient assembly onto mature virions resulting in productive infection of primary CD4(+) T cells.
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