Journal
VIROLOGY
Volume 452, Issue -, Pages 95-116Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2013.12.036
Keywords
Entomopoxvirus; Alphaentomopoxyirus; Genome; Terminal hairpin loop; Apoptosis inhibition; DNA replication
Categories
Funding
- JSPS KAKENHI [21380044]
- Grants-in-Aid for Scientific Research [21380044] Funding Source: KAKEN
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Complete genome sequence of Anomala cuprea entomopoxvirus, which belongs to the genus Alphaentomopoxvirus, including its terminal hairpin loop sequences, is reported. This is the first genome sequence of Alphaentomopoxvirus reported, and hairpin loops in entomopoxviruses have not previously been sequenced. The genome is 245,717 bp, which is smaller than had previously been estimated for Alphaentomopoxvirus. The inverted terminal repeats are quite long, and experimental results suggest that one genome molecule has one type of hairpin at one end and another type at the other end. The genome contains unexpected ORFs, e.g., that for the ubiquitin-conjugating enzyme E2 of eukaryotes. The BIR and RING domains found in a single ORF for an inhibitor of apoptosis in baculoviruses and entomopoxviruses occurred in two different, widely separated ORFs. Furthermore, an ORF in the genome contains a serpin domain that was previously found in vertebrate poxviruses for apoptosis inhibition but not in insect viruses. (C) 2014 Elsevier Inc. All rights reserved.
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