Journal
VIROLOGY
Volume 464, Issue -, Pages 218-227Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.07.021
Keywords
EV71; Dexamethasone; Mice; Lymphocyte; Anti-inflammatory
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Funding
- Headquarters of University Advancement at the National Cheng Kung University - Ministry of Education, Taiwan, Republic of China [D103-35B08]
- National Health Research Institute in Taiwan [NHRI-EX97-9530N]
- Center of Infectious Disease and Signaling Research in National Cheng Kung University
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Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4(+) T cells, CD8(+) T cells, and CD19(+) B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection. (C) 2014 Elsevier Inc. All rights reserved.
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