Journal
VIROLOGY
Volume 464, Issue -, Pages 320-329Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.07.015
Keywords
Flavivirus; Isolate; Mosquito; Complete genome; Phylogenetic analysis
Categories
Funding
- Academy of Finland
- Boehringer Ingelheim Fonds
- Biomedicum Helsinki Foundation
- Emil Aaltonen foundation
- HUSLAB
- Wellcome Trust [039833]
- EU [260644, 278433]
- [088789]
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Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector-borne transmission require further characterization. The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector-borne flaviviruses. (C) 2014 The Authors. Published by Elsevier Inc.
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