Journal
VIROLOGY
Volume 442, Issue 2, Pages 101-113Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2013.04.018
Keywords
Transcriptome; Phycodnaviridae; Phytoplankton; RNA silencing; RNA directed DNA methylation; Post-transcriptional gene silencing
Categories
Funding
- NSF-EPSCoR [EPS-1004094]
- COBRE program of the National Center for Research Resources [P20-RR15635]
- Ruth L. Kirschstein National Research Service Award from the National Institute of Allergy and Infectious Diseases [1T32AI060547]
- [DOE-DE-EE0003142]
- EPSCoR [GRANTS:14056165] Funding Source: National Science Foundation
- Office Of The Director [GRANTS:14056165] Funding Source: National Science Foundation
- Office Of The Director
- EPSCoR [1004094] Funding Source: National Science Foundation
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With growing industrial interest in algae plus their critical roles in aquatic systems, the need to understand the effects of algal pathogens is increasing. We examined a model algal host-virus system, Chlorella variabilis NC64A and virus, PBCV-1. C variabilis encodes 375 homologs to genes involved in RNA silencing and in response to virus infection in higher plants. Illumina RNA-Seq data showed that 325 of these homologs were expressed in healthy and early PBCV-1 infected (<= 60 min) cells. For each of the RNA silencing genes to which homologs were found, mRNA transcripts were detected in healthy and infected cells. C variabilis, like higher plants, may employ certain RNA silencing pathways to defend itself against virus infection. To our knowledge this is the first examination of RNA silencing genes in algae beyond core proteins, and the first analysis of their transcription during virus infection. (C) 2013 Elsevier Inc. All rights reserved.
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