Journal
VIROLOGY
Volume 434, Issue 2, Pages 175-180Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.09.027
Keywords
Viral genomics; Genome annotation; Biological sequence databases
Categories
Funding
- Intramural Research Program of the NIH, National Library of Medicine
- SIB Swiss Institute of Bioinformatics
- NIGMS [U24GM088849]
- NIH [R01 GM089636]
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The revolution in virus genome sequencing promises to effectively map the extant biological universe and reveal fundamental relationships between viral biology, genome structure, and evolution. Indeed, microbial virus genomes include large numbers of conserved coding sequences of unknown function as well as unique gene combinations, implying that that these viruses will be a significant source of novel protein biochemistry and genome architecture. Yet, making sense of the approaching phalanx of A's, G's, Ts, and C's stretching across the genome sequencing horizon will require innovation and an unprecedented coordination of annotation efforts among stakeholders. Published by Elsevier Inc.
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