Journal
VIROLOGY
Volume 415, Issue 2, Pages 160-167Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.03.012
Keywords
Innate immunity; Fc receptors; Antibody-dependent cellular phagocytosis; HIV-1
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Funding
- National Institute of Health [R01 A1080289]
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In addition to neutralization, antibodies mediate other antiviral activities including antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), as well as complement deposition. While it is established that progressive HIV infection is associated with reduced ADCC and ADCP, the underlying mechanism for this loss of function is unknown. Here we report considerable changes in FcR expression over the course of HIV infection on both mDCs and monocytes, including elevated Fc gamma RI expression in acute HIV infection and reduced expression of Fc gamma RII and Fc gamma RIIIa in chronic HIV infection. Furthermore, selective blockade of Fc gamma RII alone was associated with a loss in ADCP activity, suggesting that Fc gamma RII plays a central role in modulating ADCP. Overall, HIV infection is associated with a number of changes in FcR expression on phagocytic cells that are associated with changes in their ability to respond to antibody-opsonized targets, potentially contributing to a failure in viral clearance in progressive HIV-1 infection. (C) 2011 Elsevier Inc. All rights reserved.
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