Journal
VIROLOGY
Volume 421, Issue 1, Pages 78-84Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.09.006
Keywords
Th17 cell; Treg cell; Coxsackievirus B; Viral myocarditis
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Funding
- National Natural Science Foundation of China [30772021, 31070786]
- Research Fund for the Doctoral Program of Higher Education of China [20090071110076]
- Fudan University
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IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-beta, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC. (C) 2011 Elsevier Inc. All rights reserved.
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