Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 15, Issue 7, Pages 803-824Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.2015.1058162
Keywords
escalation therapy; induction therapy; multiple sclerosis; oral drugs; safety; therapy
Categories
Funding
- Biogen Idec
- Genzyme
- Novartis
- Teva
- Merck-Serono
- Almirall
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Multiple sclerosis (MS) is characterized by demyelination and axonal loss that results in progressive disability. Recent advances in understanding the immune pathogenesis of MS resulted in the introduction of numerous effective drugs with diverse mechanisms of actions, routes of administration and benefit-risk profiles. New oral drugs recently approved for MS treatment has led to significant achievements in MS management. The oral route of administration promotes patient satisfaction and increases therapeutic compliance; but their introduction has raised concerns regarding safety and tolerability; and a thorough analysis of the benefit/risk ratio is required. This article reviews the mechanisms of action, safety and efficacy of the licensed and experimental oral drugs in MS. Moreover, we put into perspective the disease, drug and patient-related factors that should be taken into account when considering the appropriate oral drug and treatment strategy to the appropriate patient, thus paving the road for personalized medicine in MS.
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